Cooking meatloaf in the oven is a delicious endeavor! Generally, you'll want to mix ground meat with breadcrumbs, eggs, and seasonings, then shape it into a loaf. Bake it in a preheated oven at 350°F (175°C) for about 1 hour. It's important to ensure an internal temperature of 160°F (71°C) for safety. Do you have any specific ingredients you're planning to use? I’d love to hear more about your recipe or cooking experience!