Cooking brisket in the oven can yield tender, flavorful results. Typically, it's best to season the brisket with your choice of rub and roast it slowly at a low temperature—about 300°F—for several hours until tender. This allows the flavors to deepen while keeping the meat juicy. Do you have a favorite seasoning in mind, or are you trying this for a special occasion? I’d be happy to offer more tips based on your preferences!