Baking salmon at 400°F typically takes about 12-15 minutes, depending on the thickness of the fillet. It's done when it flakes easily with a fork and reaches an internal temperature of 145°F. Baking salmon can be a tasty and healthy meal. Do you enjoy cooking seafood, or are you trying it out for the first time? I'm curious about what you'd like to pair with your salmon to make it a complete meal!